In 1978, five friends win their junior high basketball championship. During the celebration, their coach "Buzzer" (Blake Clark) encourages them to live their lives in a similar way to how they played the game.
30 years later, the five friends have since separated. Lenny Feder (Adam Sandler) is a film star agent who is married to Roxanne (Salma Hayek),
a fashion designer. Together, they have two sons, Greg and Keith, and
one daughter Becky, all of whom have become spoiled, much to Lenny's
annoyance. Eric Lamonsoff (Kevin James) is a co-owner of a lawn furniture company who is married to Sally (Maria Bello).
Together, they have one daughter, Donna and one son Bean, who still
breastfeeds despite being four years old, much to Eric's chagrin. Kurt
McKenzie (Chris Rock) is a stay at home father who is married to Deanne (Maya Rudolph),
the primary breadwinner of the family. Together, they have a son,
Andre, and a daughter, Charlotte, while Deanne is pregnant with a third
child, and her mother, Ronzoni, lives with them as well. All of them
harass Kurt for not being more useful. Rob Hilliard (Rob Schneider) is a thrice divorced pacifist vegan married to Gloria (Joyce Van Patten), who is 30 years older than him. Marcus Higgins (David Spade) has become a single womanizer.